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PARP Mouse Monoclonal Antibody(M3) |
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Catalog |
XHY159M |
XHY159L |
Quantity |
50µL |
100µL |
For research use only.
Application: WB
Species Cross-Reactivity: H
Molecular Weight: 116KD
Isotype: IgG1
Storage Buffer & Condition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Store : -20°C. Do not aliquot the antibody.
Recommended dilutions: WB: 1:1,000-3,000
Optimal dilutions should be determined by the end user.
Specificity: Antibody can detects endogenous PARP protein.
Background: Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD + ADP-ribosyltransferase 1 or
poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role
in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or
inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1,
when these breaks are encountered during DNA replication, the replication fork
stalls, and double-strand DNA (dsDNA) breaks accumulate. .
Applications:WB-Western blot IHC-Immunochemistry IF-Immunofluorescence IP-Immunoprecipitation
ChIP-Chormatin Immunoprecipitation
Reactivity: H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep