For research use only.

Applications: IHC  

Species Cross-Reactivity: H,M,R

Molecular Weight: ~113KD     

Isotype: IgG1

Storage Buffer & Condition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Store : -20°C. Do not aliquot the antibody.

Recommended dilutions: IHC: 1:200

Optimal dilutions should be determined by the end user.

Specificity: The CD21 antibody detects endogenous CD21 proteins. 

Background: CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa

protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series

of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the

Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger

CD23 signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and

upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical

monocyte functions that may be relevant to allergic and inflammatory disorders.

Applications:WB-Western blot   IHC-Immunochemistry   IF-Immunofluorescence   IP-Immunoprecipitation  

                            ChIP-Chormatin Immunoprecipitation

Reactivity:   H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep